When deciding between Acquia Site Studio and Layout Builder for your organization there's a bigger upfront cost with Site Studio which gets offset by the long term maintenance cost of custom code and contrib code needed to support Layout Builder. Layout Builder is more portable as it does not need the application be hosted on Acquia Cloud and can also support external design system tools, such as Storybook. Site Studio has a lot more features than Layout Builder if you are looking for a fully fledged solution that can support the entire application and not only its content section. It also comes with full multilingual and translation management support out of the box. Since Site Studio can control the entire page of the application a good designer/developer can quickly create an application using just the UI and empower their end users in taking ownership of their content and pages to the fullest degree.
At the end of the day, the most important question is who is your target audience and who are you trying to enable the most. As developers, we build tools that fit our audience. Site Studio shines at providing non-developer roles with an easy to understand user experience that is second to none. Layout Builder opens up the flexibility for developers to build what they need at the expense of the user experience. Choose whichever fits you and your team's needs best!